HA PRP tarin Tube

Babban canje-canjen pathophysiological na gwiwa osteoarthritis shine asarar guringuntsi, sake gina kasusuwa na subchondral, samuwar osteophyte da kumburin synovial.Abubuwan bayyanar asibiti na farko sune kumburi, zafi da ƙumburi na haɗin gwiwa da ƙwayoyin da ke kewaye.Tare da ci gaba da cutar, sannu a hankali yana haifar da rashin aiki na haɗin gwiwa kuma yana rinjayar yanayin rayuwa sosai.Bisa ga binciken, yawan nakasassun osteoarthritis a duniya ya kai kashi 2.2% a shekarar 2010, kuma adadin nakasassu a wannan shekarar ya zarce miliyan 1.7, wanda ya kawo babbar illa ga al'umma, iyalai da kuma daidaikun mutane.HA babban nau'in kwayoyin halitta ne na polysaccharide wanda aka samo ta ta maimaita maimaitawar n-acetylglucuronic acid.Shi ne babban bangaren haɗin gwiwar ruwa na synovial kuma daya daga cikin abubuwan da ke cikin matrix na guringuntsi.Yana taka rawa a cikin abinci mai gina jiki da kuma kariya ga gidajen abinci.HA a cikin maganin osteoarthritis an tabbatar da shi a asibiti yana da wani tasiri akan kawar da alamun ciwon gwiwa da inganta motsin gwiwa.Duk da haka, saboda rashin goyon bayan tushen shaida, musamman ma rashin tabbas na tsawon lokaci mai tsawo, sababbin jagororin AAOS don ganewar asali da kuma kula da ciwon osteoarthritis na gwiwa ba su bada shawarar yin amfani da hyaluronic acid ba, kuma an bada shawarar matakin shawarar sosai.Triamcinolone acetonide, a matsayin glucocorticoid na roba na dogon lokaci, yana da tasiri mai ƙarfi kuma mai dorewa.

Hanyarsa ita ce hana phagocytosis da sarrafa antigens ta macrophages;Tabbatar da membrane lysosomal kuma rage sakin hydrolase a cikin lysosome;Hana ƙaura na leukocytes da macrophages daga tasoshin jini da rage kumburi.Wannan binciken ya nuna cewa tasirin allurar intra-articular na triamcinolone acetonide yana da kyau a cikin wata daya bayan jiyya, amma tare da lokacin ritaya, musamman bayan watanni 6 na jiyya, tasirin yana da ƙasa da sauran ƙungiyoyin biyu.Mcalindon da sauran nazarin sun nuna cewa ga marasa lafiya da ke fama da osteoarthritis na gwiwa, allurar intraarticular na triamcinolone acetonide ya haifar da hasara mai girma na guringuntsi kuma babu wani bambanci a cikin ciwon gwiwa idan aka kwatanta da saline na al'ada.

Abubuwan da ke sama ba su goyi bayan wannan magani ga marasa lafiya masu alamar cututtuka tare da osteoarthritis na gwiwa ba.Wasu masu bincike sun yi amfani da triamcinolone acetonide da sodium hyaluronate intra-articular allura don magance osteoarthritis gwiwa gwiwa, kuma tasirinsa na gajeren lokaci da na dogon lokaci ya fi na hyaluronic acid kadai.A matsayin sabon magani, ana iya samun PRP daga jini mai sarrafa kansa na marasa lafiya, ba tare da kin amincewa da rigakafi ba, kuma ya ƙunshi babban abubuwan haɓaka.An tabbatar da abubuwan haɓaka don haɓaka haɓakar chondrocyte da haɓakar matrix na waje.Bugu da ƙari, karatun kwanan nan sun nuna cewa PRP na iya hana ƙwayar ƙwayar ƙwayar ƙwayar cuta ta Mynovium zuwa wani lokaci yayin inganta sabuntawa ta Chendocyte.Ƙarin gwaje-gwajen dabba da nazarin asibiti suna nuna kyakkyawan ingancinsa.Wannan binciken ya nuna cewa makin WOMAC na PRP a watanni 1 da 3 bayan jiyya yana daidai da na hyaluronic acid, kuma makin WOMAC na PRP a watanni 6 bayan jiyya ya fi na sauran ƙungiyoyi biyu, yana nuna cewa yana da mai kyau matsakaici da kuma dogon lokaci curative sakamako.Duk da haka, saboda rashin binciken binciken asibiti na dogon lokaci na manyan samfurori da kuma rashin goyon bayan kai tsaye daga ƙarin ilimin kwayoyin halitta ko MRI, ana buƙatar ƙarin bincike da tattaunawa.